PYC Therapeutics (ASX: PYC), a clinical-stage biotechnology company, has announced the presentation of clinical trial data for its drug candidate VP-001 at the Asia Pacific Vitreo-Retina Society (APVRS) conference in Singapore on November 23, 2024. At the time of writing, VP-001 is being developed as the first treatment for Retinitis Pigmentosa type 11 (RP11), a rare childhood eye disease. Associate Professor Fred Chen of the Lions Eye Institute will present Phase 1/2 trial results, highlighting improvements in retinal sensitivity and Low Luminance Visual Acuity (LLVA) in treated patients compared to baseline and untreated eyes. VP-001 targets the genetic cause of RP11 by restoring PRPF31 protein levels.
Granted orphan drug and fast-track designations by the FDA, it marks a major breakthrough in tackling this AU$1 billion annual market opportunity. PYC is preparing for FDA engagement in 2025 to design a registrational trial anticipated to begin mid-year.
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