Nyrada Inc (ASX: NYR), a drug development company specializing in cardiovascular and neurological diseases, announced that its cholesterol-lowering drug candidate will not proceed to the planned Phase I/IIa clinical trial due to an adverse signal observed in a toxicology study. While the drug candidate showed no unusual safety signals in most studies, the pathology analysis revealed adverse findings in response to the drug in a number of animal subjects during the 28-day study.
After consulting with a toxicologist and the US Contract Research Organization, it was determined that the drug candidate is not suitable for advancement into human trials. Despite the setback, Nyrada remains committed to developing an oral small molecule PCSK9 inhibitor drug for lowering high cholesterol. Nyrada focuses on developing drugs for cardiovascular and neurological diseases, including cholesterol-lowering and brain injury treatments.
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