AGNs ARG-007 proves effective standalone therapy in hypoxic-ischaemic encephalopathy preclinical study

Oct 18, 2023

Argenica Therapeutics Limited (ASX: AGN) has revealed significant progress in its neuroprotective drug candidate, ARG007, designed to mitigate brain tissue damage in neurological disorders. In a preclinical model of hypoxic-ischaemic encephalopathy (HIE), ARG007 demonstrated remarkable efficacy. The study showcased a 46% reduction in total brain injury compared to a saline placebo and a 42% reduction compared to therapeutic hypothermia 48 hours post-HIE.

Impressively, even 4 weeks after the event, a single dose of ARG007 sustained a 52% reduction in total brain injury compared to saline and a 57% reduction compared to therapeutic hypothermia. These promising results suggest ARG007 could serve as a valuable neuroprotection therapy for HIE, either in conjunction with hypothermia or as a standalone treatment when hypothermia is not feasible. Argenica plans to further validate these findings through larger animal studies and complete essential juvenile toxicology studies.

 

 

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