Immutep Limited (ASX: IMM) announced new favorable clinical data from INSIGHT-003, an investigator-initiated Phase I trial in first-line non-small cell lung cancer conducted by the Frankfurt Institute of Clinical Cancer Research IKF. In INSIGHT-003, a soluble LAG-3 protein and MHC Class II agonist called eftilagimod alpha ("efti") is being tried for the first time in conjunction with the anti-PD-1 therapy that is considered to be the gold standard and doublet chemotherapy (carboplatin/pemetrexed).
The triple combination therapy is still well-tolerated and shows good early efficacy signals, with a 67% overall response rate (ORR) and a 91% disease control rate (DCR) in advanced or metastatic non-squamous 1st line non-small cell lung cancer patients (N=21). Notably, 81% (17/21) of patients had a PDL1 Tumour Proportion Score (TPS) of 50%, indicating that they are less sensitive to anti-PD-1-based therapy than PD-L1 high-expressing patients.
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Nextgen Global Services Pty Ltd trading as Kapitales Research (ABN 89 652 632 561) is a Corporate Authorised Representative (CAR No. 1293674) of Enva Australia Pty Ltd (AFSL 424494). The information contained in this website is general information only. Any advice is general advice only. No consideration has been given or will be given to the individual investment objectives, financial situation or needs of any particular person. The decision to invest or trade and the method selected is a personal decision and involves an inherent level of risk, and you must undertake your own investigations and obtain your own advice regarding the suitability of this product for your circumstances. Please be aware that all trading activity is subject to both profit & loss and may not be suitable for you. The past performance of this product is not and should not be taken as an indication of future performance.
